منابع مشابه
Cell Migration: Katanin Gives Microtubules a Trim
New evidence suggests that katanin - best known for severing microtubules in their more stable regions - localizes at the leading edge of migratory cells and trims microtubules at their dynamic plus ends.
متن کاملRegulation of cell migration by dynamic microtubules.
Microtubules define the architecture and internal organization of cells by positioning organelles and activities, as well as by supporting cell shape and mechanics. One of the major functions of microtubules is the control of polarized cell motility. In order to support the asymmetry of polarized cells, microtubules have to be organized asymmetrically themselves. Asymmetry in microtubule distri...
متن کاملThe role of microtubules and their dynamics in cell migration.
Although microtubules have long been implicated in cell locomotion, the mechanism of their involvement remains controversial. Most studies have concluded that microtubules play a positive role by regulating actin polymerization, transporting membrane vesicles to the leading edge, and/or facilitating the turnover of adhesion plaques. Here we used wild-type and mutant CHO cell lines with alterati...
متن کاملMicrotubules and Lis-1/NudE/Dynein Regulate Invasive Cell-on-Cell Migration in Drosophila
The environment through which cells migrate in vivo differs considerably from the in vitro environment where cell migration is often studied. In vivo many cells migrate in crowded and complex 3-dimensional tissues and may use other cells as the substratum on which they move. This includes neurons, glia and their progenitors in the brain. Here we use a Drosophila model of invasive, collective mi...
متن کاملThe Coxsackie and adenovirus receptor (CAR) binds microtubules and plays a role in cell migration
The Coxsackie and adenovirus receptor (CAR), a cell adhesion molecule of the immunoglobulin superfamily, inhibits cell growth of a variety of tumors. The cytoplasmic domain of CAR has been implicated in decreased invasion and intracerebral growth of human U87 glioma cells. Using affinity binding, we identified tubulin as an interaction partner for the cytoplasmic domain of CAR. The interaction ...
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ژورنال
عنوان ژورنال: Essays in Biochemistry
سال: 2019
ISSN: 0071-1365,1744-1358
DOI: 10.1042/ebc20190016